Left Hand began in December 1990 with a homebrewing kit founder Dick Doore received from his brother. According to Dick, "it was all downhill from there." By 1993, Dick had teamed up with college buddy Eric Wallace and they resolved to start a brewery.

On September 21, 1993, they incorporated as Indian Peaks Brewing Company, and purchased a former meat-packing plant next to the St. Vrain River outside downtown Longmont, Colorado. A few weeks after beginning production, it was discovered that the name Indian Peaks was already in use by another Brewery, so the name was changed to Left Hand, in honor of Chief Niwot (the Arapahoe word for "left hand") whose tribe wintered in the local area.