The origin of the name Vieux Lazaret dates back to the 18th century when there existed in the centre of the village of Châteauneuf-du-Pape a hospice or Lazaret. This offered comfort and shelter for the poor and infirm, provided by the Lazarists, who were a silent order of monks founded in 1625 by St Vincent de Paul to look after the sick and the needy in the French countryside. They took the name Lazarists from the Priory of St Lazare in Paris, where the original order had been formed in 1632.

The Lazarists in Châteauneuf-du-Pape played a major role in taking in and looking after the sick during the terrible epidemic of the plague, which killed a third of the population in 1720. Subsequently the buildings fell into disuse and were sold by the Commune during the 19th century to the Quiot family and used as agricultural buildings. Being situated in the village of Châteauneuf-du-Pape and close to other properties owned by the Quiot family, these original buildings have today been extended and modernized, and now form the center of winemaking for Vignobles Famille Quiot. With this historical association going back over several centuries, the Quiot family decided in 1915 to give the name of Domaine du Vieux Lazaret to their principal Domaine.

Today, Domaine du Vieux Lazaret is exported to more than 43 countries around the world. It can be found on the best tables and regularly wins medals in wine competitions throughout the world. Florence and Jean Baptiste are the 13th generation to work at the estate.